Acryloyl chloride → 4-Acrylamido-2-bromothiazole

HRID 2419324Notes

Reaction equation

[NH2:1][C:2]1[N:3]=[C:4]([Br:7])[S:5][CH:6]=1.[C:8](Cl)(=[O:11])[CH:9]=[CH2:10]>>[C:8]([NH:1][C:2]1[N:3]=[C:4]([Br:7])[S:5][CH:6]=1)(=[O:11])[CH:9]=[CH2:10]

Participants

Reactant 2

HCID 13140Acryloyl chloride

HCID 202940422-Bromo-1,3-thiazol-4-amine

Product 1

HCID 203771664-Acrylamido-2-bromothiazole

Procedure

4-Amino-2-bromothiazole is treated with acryloylchloride to give 4-acrylamido-2-bromothiazole which is refluxed with sodium in absolute methanol for sufficient time to produce the title compound.

Sources & evidence

ORD record: ord-a22564a2ff784d88869e75707cbd69da
Source dataset: uspto-grants-1978_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04105773

Reaction notes

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