反应详情

Potassium carbonate (17.0g.) was added to a solution of isopropyl bromoacetate (24.0g.) and 4-hydroxyacetophenone (17.7g.) in acetone (200ml.). The mixture was heated under reflux for 24 hours, cooled and filtered. The filtrate was evaporated to an oil which was dissolved in ether (150ml.). The solution was washed with sodium bicarbonate solution (2 × 30ml.), water (2 × 30ml.), dried and evaporated. The residual oil was distilled to give isopropyl 4-acetylphenoxyacetate, I.R. peaks at 1750 and 1670 cm-1.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 24 hours
3. temperaturecooled
4. filtrationfiltered
5. customThe filtrate was evaporated to an oil which
6. dissolutionwas dissolved in ether (150ml.)
7. washThe solution was washed with sodium bicarbonate solution (2 × 30ml.), water (2 × 30ml.)
8. customdried
9. customevaporated
10. distillationThe residual oil was distilled