Bromine → HCID 20315597, compound

HRID 2419359Notes

Reaction equation

HRID 2419359 reaction equation
[Br:1]Br.[C:3]([C:6]1[CH:21]=[CH:20][C:9]([O:10][CH2:11][C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[O:13])=[CH:8][CH:7]=1)(=[O:5])[CH3:4]>C(Cl)(Cl)Cl>[Br:1][CH2:4][C:3]([C:6]1[CH:21]=[CH:20][C:9]([O:10][CH2:11][C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[O:13])=[CH:8][CH:7]=1)=[O:5]

Participants

4

Reactant 2

HCID 24408BromineHCID 34762Acetophenone, 4'-morpholinocarbonylmethoxy-

Product 1

HCID 20315597HCID 20315597, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of bromine (8.0g.) in chloroform (30ml.) was added dropwise to a stirred solution of 4-(4-acetylphenoxyacetyl)morpholine (13.15g.) in chloroform (120ml.) at 35° C. After 1 hour, the reaction mixture was filtered and the filtrate was washed with water (2 × 30ml.), dried and evaporated. The residue was recrystallised from methanol/ether to give 4-[4-(bromoacetyl)phenoxyacetyl]morpholine, m.p. 105°-107° C.

Workup

  1. filtrationthe reaction mixture was filtered
  2. washthe filtrate was washed with water (2 × 30ml.)
  3. customdried
  4. customevaporated
  5. customThe residue was recrystallised from methanol/ether

Sources & evidence

ORD record
ord-85740456960642d68192ad4be19c2414
Source dataset
uspto-grants-1978_08
Patent number
US04105790

Reaction notes

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