Hydrochloric Acid → HCID 20315587, compound

HRID 2419376Notes

Reaction equation

HRID 2419376 reaction equation
[ClH:1].[NH2:2][CH2:3][C:4]([C:6]1[CH:19]=[CH:18][C:9]([O:10][CH:11]([CH3:17])[C:12]([O:14][CH2:15]C)=[O:13])=[CH:8][CH:7]=1)=[O:5].Cl>CO.CCOCC>[ClH:1].[NH2:2][CH2:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([O:10][CH:11]([CH3:17])[C:12]([O:14][CH3:15])=[O:13])=[CH:18][CH:19]=1)=[O:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 20315553HCID 20315553, compound

Product 1

HCID 20315587HCID 20315587, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of ethyl 2-[4-(aminoacetyl)phenoxy]-propionate hydrochloride (2.0g.) in a mixture of methanol (150ml.) and a saturated solution of hydrogen chloride in ether (1ml.) was stirred and heated under reflux for 48 hours. The reaction mixture was then evaporated in vacuo and the residue was triturated with ether (50ml.) (dried over sodium wire) to give methyl 2-[4-(aminoacetyl)phenoxy]propionate hydrochloride which was isolated as a hygroscopic solid (1.3g.) having a satisfactory analysis; found: C, 50.0%; H, 5.9%, N, 4.9%; required (+ 3/4 mole H2O): C, 50.2%; H, 6.1%; N, 4.9%.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 48 hours
  3. customThe reaction mixture was then evaporated in vacuo
  4. customthe residue was triturated with ether (50ml.) (dried over sodium wire)

Sources & evidence

ORD record
ord-89e5851229814844b64880b19da239ff
Source dataset
uspto-grants-1978_08
Patent number
US04105790

Reaction notes

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