Hydrochloric Acid → HCID 20315600, compound

Participants

Reaction Steps

A mixture of 4-methoxycarbonyl-5-[4-(methoxycarbonylmethoxy)phenyl]oxazole (2.34g.) and a saturated solution of hydrogen chloride in methanol (20ml.) was heated under reflux for 2 hours. The reaction mixture was then evaporated in vacuo and the yellow residue obtained was triturated with ether (100ml.) (dried over sodium wire) to give methyl 4-(α-amino-α-methoxycarbonylacetyl)phenoxyacetate hydrochloride as an off-white amorphous solid (1.9g.), m.p. 120°-125° C., having a satisfactory analysis; found: C, 48.9%; H, 5.1%; N, 4.2%; required: C, 49.2%; H, 5.05%; N, 4.42%.

Provenance & Evidence