Hydrochloric Acid → HCID 20315600, compound

HRID 2419377Notes

Reaction equation

HRID 2419377 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=C[O:8][C:9]=1[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])=[CH:12][CH:11]=1)=[O:4].[ClH:22]>CO>[ClH:22].[NH2:6][CH:5]([C:3]([O:2][CH3:1])=[O:4])[C:9]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])=[CH:12][CH:11]=1)=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20315592HCID 20315592, compound

Product 1

HCID 20315600HCID 20315600, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4-methoxycarbonyl-5-[4-(methoxycarbonylmethoxy)phenyl]oxazole (2.34g.) and a saturated solution of hydrogen chloride in methanol (20ml.) was heated under reflux for 2 hours. The reaction mixture was then evaporated in vacuo and the yellow residue obtained was triturated with ether (100ml.) (dried over sodium wire) to give methyl 4-(α-amino-α-methoxycarbonylacetyl)phenoxyacetate hydrochloride as an off-white amorphous solid (1.9g.), m.p. 120°-125° C., having a satisfactory analysis; found: C, 48.9%; H, 5.1%; N, 4.2%; required: C, 49.2%; H, 5.05%; N, 4.42%.

Workup

  1. temperatureunder reflux for 2 hours
  2. customThe reaction mixture was then evaporated in vacuo
  3. customthe yellow residue obtained
  4. customwas triturated with ether (100ml.) (dried over sodium wire)

Sources & evidence

ORD record
ord-a482c70a00cc41028e4c19e9cec13f7b
Source dataset
uspto-grants-1978_08
Patent number
US04105790

Reaction notes

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