反应详情

温度

100 °C

A mixture of methyl 4-(aminoacetyl)phenoxyacetate hydrochloride (2.6g.) and trimethyl orthoformate (3.18g.) was stirred at 100° C. for 1 hour under reflux. The volatile reaction products were then allowed to distil off. The yellow residual oil thus obtain crystallised on cooling to give methyl 4-[(N-formyl)aminoacetyl]phenoxyacetate as a solid (2.2g.), m.p. 116° C., after recrystallisation from methanol.

1. temperatureunder reflux
2. customto distil off
3. customThe yellow residual oil thus obtain
4. customcrystallised
5. temperatureon cooling