HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2419379Generated: November 3, 2026
Trimethyl orthoformate → methyl 4-[(N-formyl)aminoacetyl]phenoxyacetate
https://huagongshe.com/reaction/2419379
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | Methyl 4-(aminoacetyl)phenoxyacetate hydrochloride | HCID 20315552 | — |
| Product | methyl 4-[(N-formyl)aminoacetyl]phenoxyacetate | HCID 20315613 | — |
Reaction Steps
A mixture of methyl 4-(aminoacetyl)phenoxyacetate hydrochloride (2.6g.) and trimethyl orthoformate (3.18g.) was stirred at 100° C. for 1 hour under reflux. The volatile reaction products were then allowed to distil off. The yellow residual oil thus obtain crystallised on cooling to give methyl 4-[(N-formyl)aminoacetyl]phenoxyacetate as a solid (2.2g.), m.p. 116° C., after recrystallisation from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04105790 |
|---|
| Source dataset | uspto-grants-1978_08 |
|---|
| ORD ID | ord-98f6269932f3487e92edcb900106ee53 |
|---|
| Source note | uspto-grants-1978_08 |
|---|
