Hydrochloric Acid → HCID 85904055, compound

HRID 2419380Notes

Reaction equation

HRID 2419380 reaction equation
C([NH:3][CH2:4][C:5]([C:7]1[CH:18]=[CH:17][C:10]([S:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:9][CH:8]=1)=[O:6])=O.[ClH:19]>CO>[ClH:19].[NH2:3][CH2:4][C:5]([C:7]1[CH:8]=[CH:9][C:10]([S:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:17][CH:18]=1)=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 85904064HCID 85904064, compound

Product 1

HCID 85904055HCID 85904055, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of methyl 4-[N-(formyl)aminoacetyl]-thiophenoxyacetate (10.1g.) and a saturated solution of hydrogen chloride in methanol (100ml.) was left at room temperature for 4 days. The mixture was then evaporated in vacuo and the residue recrystallised from a mixture of ether and methanol to give methyl 4-(aminoacetyl)thiophenoxyacetate hydrochloride (Example 33) (9.5g.), m.p. 161°-165° C. (decomposition, monohydrate).

Workup

  1. customThe mixture was then evaporated in vacuo
  2. customthe residue recrystallised from a mixture of ether and methanol

Sources & evidence

ORD record
ord-b0f958b86c2e47bd93afd1f3593899fc
Source dataset
uspto-grants-1978_08
Patent number
US04105790

Reaction notes

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