Benzhydrol → 1-[3-[(diphenylmethyl)thio]-2-benzylpropanoyl]-L-proline

HRID 2419439Notes

Reaction equation

HRID 2419439 reaction equation
[C:1]1([CH:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[SH:15][CH2:16][CH:17]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:18]([N:20]1[CH2:27][CH2:26][CH2:25][C@H:21]1[C:22]([OH:24])=[O:23])=[O:19]>FC(F)(F)C(O)=O>[C:1]1([CH:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[S:15][CH2:16][CH:17]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:18]([N:20]2[CH2:27][CH2:26][CH2:25][C@H:21]2[C:22]([OH:24])=[O:23])=[O:19])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 7037BenzhydrolHCID 183972851-[3-Phenyl-2-(sulfanylmethyl)propanoyl]-L-proline

Product 1

HCID 543808381-[3-[(diphenylmethyl)thio]-2-benzylpropanoyl]-L-proline

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Diphenylmethanol (0.92 g) and 1-(3-mercapto-2-benzylpropanoyl)-L-proline (1.5 g) are dissolved in trifluoroacetic acid (10 ml) and the solution is kept at room temperature for 30 minutes. The excess trifluoroacetic acid is removed in vacuo to yield 1-[3-[(diphenylmethyl)thio]-2-benzylpropanoyl]-L-proline.

Workup

  1. customThe excess trifluoroacetic acid is removed in vacuo

Sources & evidence

ORD record
ord-ed275a81d35b437fa6e87433673a882d
Source dataset
uspto-grants-1978_08
Patent number
US04105776

Reaction notes

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