6-Chloronicotinoyl Chloride → HCID 58563708, compound

HRID 241947Notes

Reaction equation

HRID 241947 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH2:5][N:4]2[N:8]=[C:9]([C:11]([OH:13])=[O:12])[CH:10]=[C:3]12.[Cl:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][N:16]=1>>[Cl:14][C:15]1[N:16]=[CH:17][C:18]([C:19]([CH:7]2[CH2:6][CH2:5][N:4]3[N:8]=[C:9]([C:11]([OH:13])=[O:12])[CH:10]=[C:3]3[C:2]2=[O:1])=[O:20])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 27821656-Chloronicotinoyl ChlorideHCID 226053224-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid

Product 1

HCID 58563708HCID 58563708, compound

Procedure

A-07 is prepared using general procedure A2 starting from 4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridine-2-carboxylic acid (5.00 g, 27.8 mmol) and 6-chloro-nicotinoyl chloride (7.33 g, 41.6 mmol). Yield: 7.37 g. HPLC-MS: Rt=1.94 min, (M+H)+=320/322.

Workup

  1. customA-07 is prepared

Sources & evidence

ORD record
ord-ff73af7f0a40498bb500273296d61807
Source dataset
uspto-grants-2014_02
Patent number
US08653097B2

Reaction notes

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