反应详情

4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-b]pyridine 5 (0.180 g, 0.89 mmol) was dissolved in 2 mL dioxane and 2 mL acetonitriile in a microwave tube, and nitrogen was bubbled through the solution. 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole (0.217 g, 0.89 mmol) and a 1M solution of potassium acetate (2 mL, 2 mmol) were added. Nitrogen gas was bubbled through the mixture followed by the addition of 5 mole % of tetrakis(triphenylphosphine) palladium (0). The resultant mixture was microwaved at 125° C. for 30 minutes. Purification via Biotage reverse phase system (4:1 ethyl acetate/hexanes) gave 12.

1. custom2 mL acetonitriile in a microwave tube, and nitrogen was bubbled through the solution
2. customNitrogen gas was bubbled through the mixture
3. additionfollowed by the addition of 5 mole % of tetrakis(triphenylphosphine) palladium (0)
4. customThe resultant mixture was microwaved at 125° C. for 30 minutes
5. customPurification via Biotage