Ethyl 1-(methylsulfonyl)piperidine-4-carboxylate → (1-(Methylsulfonyl)piperidin-4-yl)methanol

HRID 241955Notes

Reaction equation

HRID 241955 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][CH:8]([C:11](OCC)=[O:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][CH:8]([CH2:11][OH:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 669104Ethyl 1-(methylsulfonyl)piperidine-4-carboxylateHCID 21226445Aluminium lithium hydride

Product 1

HCID 18352755(1-(Methylsulfonyl)piperidin-4-yl)methanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl 1-(methylsulfonyl)piperidine-4-carboxylate 18 was reacted with lithium aluminum hydride in THF to give 19.

Sources & evidence

ORD record
ord-b5bc7ddce0724dbd8ab61f15955d17b8
Source dataset
uspto-grants-2014_02
Patent number
US08653098B2

Reaction notes

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