2-(Diisopropylamino)ethyl chloride → alpha-(p-Fluorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-[2-(dimethylamino)ethyl]acetonitrile
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:9]#[N:10])=[CH:4][CH:3]=1.Cl[CH2:21][CH2:22][N:23]([CH3:25])[CH3:24].C(N(C(C)C)CCC(C1C=CC=CC=1)C#N)(C)C.ClCCN(C(C)C)C(C)C>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:15])[CH3:16])([CH2:21][CH2:22][N:23]([CH3:25])[CH3:24])[C:9]#[N:10])=[CH:6][CH:7]=1Participants
5
Reactant 4
Product 1
Procedure
Substitution of equivalent quantities of α-(p-fluorophenyl)-α-[2-(diisopropylamino)ethyl]acetonitrile and 2-chloro-N,N-dimethylethylamine for α-[2-(diisopropylamino)ethyl]-α-phenylacetonitrile and 2-chloro-N,N-diisopropylethylamine called for respectively in the procedure of Example 2, Method B, there is obtained α-(p-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-[2-(dimethylamino)ethyl]acetonitrile, as an oil.
Sources & evidence
- ORD record
- ord-f9eeb91683ef4b348af039198524a555
- Source dataset
- uspto-grants-1978_08
- Patent number
- US04107205
Reaction notes
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