1-Methylpiperazine → HCID 12493317, compound

HRID 2419643Notes

Reaction equation

HRID 2419643 reaction equation
CS[C:3]1[N:8]2[CH:9]=[CH:10][N:11]=[C:7]2[CH:6]=[N:5][N:4]=1.[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([C:3]2[N:8]3[CH:9]=[CH:10][N:11]=[C:7]3[CH:6]=[N:5][N:4]=2)[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 124933105-(Methylthio)-imidazo[1,2-d]-as-triazine

Product 1

HCID 12493317HCID 12493317, compound

Procedure

A 5.0 gm. portion of 5-(methylthio)-imidazo[1,2-d]-as-triazine is combined with 45 ml. of N-methylpiperazine and refluxed for 5 hours. The reaction mixture is evaporated giving a brown oil. This oil is triturated four times with 30 ml. portions of hot benzene. The combined benzene solutions are treated with charcoal, evaporated to 75 ml., retreated with charcoal, cooled and filtered, giving 1.0 gm. of the desired product, m.p. 176°-178° C. This base forms non-toxic acid-addition salts with a variety of pharmacologically acceptable organic and inorganic salt-forming reagents. Thus, acid-addition salts, formed by admixture of the organic free base with an equivalent of an acid, suitably in a neutral solvent, are formed with such acids as sulfuric, phosphoric hydrochloric, sulfamic, citric, lactic, tartaric, acetic, benzoic, gluconic, ascorbic, and related acids. For purposes of this invention, 5-(4-methyl-1-piperazinyl)-imidazo[1,2-d]-as-triazine is equivalent to its non-toxic acid-addition salts.

Workup

  1. customThe reaction mixture is evaporated
  2. customgiving a brown oil
  3. customThis oil is triturated four times with 30 ml
  4. additionThe combined benzene solutions are treated with charcoal
  5. customevaporated to 75 ml
  6. temperaturecooled
  7. filtrationfiltered
  8. customgiving 1.0 gm

Sources & evidence

ORD record
ord-1f4562d5e5034ad58da422c8cdece390
Source dataset
uspto-grants-1978_08
Patent number
US04107309

Reaction notes

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