Iodoethane → HCID 13548773, compound

HRID 2419685Notes

Reaction equation

HRID 2419685 reaction equation
[CH:1]1[C:2]2[N:3]([CH:8]=[N:9][CH:10]=2)[C:4](=[S:7])[NH:5][N:6]=1.C[O-].[Na+].I[CH2:15][CH3:16]>CO>[CH2:15]([N:5]1[C:4](=[S:7])[N:3]2[CH:8]=[N:9][CH:10]=[C:2]2[CH:1]=[N:6]1)[CH3:16]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 10942334Sodium MethoxideHCID 12493298HCID 12493298, compound

Product 1

HCID 13548773HCID 13548773, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a mixture of 3.04 g of imidazo[1,5-d]-as-triazine-4(3H)-thione and 30 ml of methanol is added a solution of 1.08 g of sodium methoxide in 10 ml of methanol. The resulting solution is treated with 1.70 ml (3.28 gm) of iodoethane. Upon evaporation, the residue is purified by preparative thin layer chromatography on silica gel. Recrystallization from acetone gives the desired product, m.p. 143°-144.5° C.

Workup

  1. customUpon evaporation
  2. customthe residue is purified by preparative thin layer chromatography on silica gel
  3. customRecrystallization from acetone

Sources & evidence

ORD record
ord-8bfeeb4ef67547f6938448cbe50c0646
Source dataset
uspto-grants-1978_08
Patent number
US04107308

Reaction notes

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