Dimethylformamide dimethyl acetal → HCID 20291411, compound

HRID 2419755Notes

Reaction equation

HRID 2419755 reaction equation
[CH3:1]OC(OC)N(C)C.[CH3:9][C:10]1[N:11]=[C:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:13]2[C:18]=1[CH:17]=[N:16][NH:15][C:14]2=[O:19]>C1C=CC=CC=1>[CH3:1][N:15]1[C:14](=[O:19])[N:13]2[C:12]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[N:11][C:10]([CH3:9])=[C:18]2[CH:17]=[N:16]1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 13548681HCID 13548681, compound

Product 1

HCID 20291411HCID 20291411, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Dimethylformamide dimethyl acetal (0.73 ml; α= 0.897, 0.005 mole) is added slowly to a slurry of 8-methyl-6-phenylimidazo[1,5-d]-as-triazin-4(3H)-one (1.13 g, 0.005 mole in benzene (25 ml). The reaction mixture is stirred, refluxed for 24 hours, cooled and filtered. The filtrate is evaporated to yield 1.4 g (100%) product. Recrystallization from methyl cyclohexane yields yellow crystals, found to be identical (ir: nmr) to the product obtained by Method A.

Workup

  1. temperaturerefluxed for 24 hours
  2. temperaturecooled
  3. filtrationfiltered
  4. customThe filtrate is evaporated

Sources & evidence

ORD record
ord-c375410ab264479582b0790d84280422
Source dataset
uspto-grants-1978_08
Patent number
US04107307

Reaction notes

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