反应详情

A solution of 93.6 g of methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydroiodide (U.S. Pat. No. 3,657,337) and 51.2 of benzylamine in 400 ml. of absolute ethanol is heated at reflux for 6 hours and then diluted while hot with 400 ml. of water, causing the separation of an oil. On standing, the oil crystallizes and the nearly colorless crystals are recovered by filtration. Recrystallization from aqueous ethanol gives the desired product as pale yellow crystals, m.p. 134°-137° C.

1. temperatureat reflux for 6 hours
2. additiondiluted while hot with 400 ml
3. customthe separation of an oil
4. customthe oil crystallizes
5. filtrationthe nearly colorless crystals are recovered by filtration
6. customRecrystallization from aqueous ethanol