2-Aminothiazole → HCID 178438812, compound

HRID 2419803Notes

Reaction equation

HRID 2419803 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH:12]([CH3:14])[CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:15](Cl)=[O:16].[NH2:18][C:19]1[S:20][CH:21]=[CH:22][N:23]=1>>[S:20]1[CH:21]=[CH:22][N:23]=[C:19]1[NH:18][C:15]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[OH:1])=[CH:10][C:9]([CH:12]([CH3:14])[CH3:13])=[CH:8][CH:7]=2)=[O:16]

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 178438811HCID 178438811, compound

Product 1

HCID 178438812HCID 178438812, compoundYield 10.5%

Procedure

Using the procedure of Example 1, 10.74 g of the product of Step D and 3.9 g of 2-amino-thiazole were reacted to obtain 1.28 g of N-(2-thiazolyl)-4-hydroxy-6-isopropyl-quinoline-3-carboxamide melting above 340° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-34ce611f7a8c4e2bb69c334b61d5b979
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

Loading…