Sodium Hydroxide → HCID 178432242, compound

HRID 2419805Notes

Reaction equation

HRID 2419805 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:16])[C:3]=1[C:17]([O:19]CC)=[O:18].[OH-].[Na+]>>[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:13])[F:14])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:16])[C:3]=1[C:17]([OH:19])=[O:18]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 178469186HCID 178469186, compound

Product 1

HCID 178432242HCID 178432242, compoundYield 94.4%

Procedure

A suspension of 19.4 g of the product of Step B in 162 ml of N sodium hydroxide was refluxed for 5 hours and the mixture was then washed with ether and modified to a pH of 1 with N hydrochloric acid. The mixture was filtered and the solid precipitate was washed with water and dried to obtain 16.6 g of 4-hydroxy-2-methyl-8-trifluoromethyl-quinoline-3-carboxylic acid melting at 260° C.

Workup

  1. temperaturewas refluxed for 5 hours
  2. washthe mixture was then washed with ether
  3. filtrationThe mixture was filtered
  4. washthe solid precipitate was washed with water
  5. customdried

Sources & evidence

ORD record
ord-67f41d2fa8fa4614b5046864ac509f5c
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

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