Sodium Hydroxide → HCID 178432242, compound

Participants

Reaction Steps

A suspension of 19.4 g of the product of Step B in 162 ml of N sodium hydroxide was refluxed for 5 hours and the mixture was then washed with ether and modified to a pH of 1 with N hydrochloric acid. The mixture was filtered and the solid precipitate was washed with water and dried to obtain 16.6 g of 4-hydroxy-2-methyl-8-trifluoromethyl-quinoline-3-carboxylic acid melting at 260° C.

Provenance & Evidence