2-Aminothiazole → HCID 178432241, compound

HRID 2419806Notes

Reaction equation

[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:16])[C:3]=1[C:17](Cl)=[O:18].[NH2:20][C:21]1[S:22][CH:23]=[CH:24][N:25]=1>>[S:22]1[CH:23]=[CH:24][N:25]=[C:21]1[NH:20][C:17]([C:3]1[C:4]([CH3:16])=[N:5][C:6]2[C:11]([C:2]=1[OH:1])=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]([F:15])([F:14])[F:13])=[O:18]

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 178432240HCID 178432240, compound

Product 1

HCID 178432241HCID 178432241, compound

Procedure

Using the procedure of Example 1, the product of Step D and 2-aminothiazole were reacted to obtain N-(2-thiazolyl)-4-hydroxy-2-methyl-8-trifluoromethyl-quinoline-3-carboxamide melting at 267° C.

Sources & evidence

ORD record: ord-fe96ad5fcf134474aaaafaa17637ec32
Source dataset: uspto-grants-1978_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04107310

Reaction notes

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