Phosphorus pentachloride → HCID 15121251, compound

HRID 2419809Notes

Reaction equation

HRID 2419809 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10](=O)[CH2:11][CH3:12].P(Cl)(Cl)(Cl)(Cl)[Cl:17]>C1(C)C=CC=CC=1>[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]=[C:10]([Cl:17])[CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 3507819HCID 3507819, compound

Product 1

HCID 15121251HCID 15121251, compoundYield 97.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 18 g of the product of Step A in 150 ml of toluene was added over 15 minutes to a suspension of 19 g of phosphorus pentachloride in 23 ml of toluene and after gas evolution ceased, the mixture was refluxed for 11/2 hours. The toluene was evaporated under reduced pressure to obtain 19 g of N-(2-trifluoromethylphenyl)-propanimidoyl chloride in the form of a yellow oil which was used as is for the next step.

Workup

  1. temperaturethe mixture was refluxed for 11/2 hours
  2. customThe toluene was evaporated under reduced pressure

Sources & evidence

ORD record
ord-1d45f5beb88c4c55be33d4f5093c0c2b
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

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