HCID 86735940, compound → HCID 178468890, compound

HRID 2419815Notes

Reaction equation

HRID 2419815 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10](=[C:14]([C:20]([O-:22])=O)[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:11]([CH3:13])[CH3:12]>C1(OC2C=CC=CC=2)C=CC=CC=1>[OH:22][C:20]1[C:5]2[C:4](=[C:3]([C:2]([F:24])([F:1])[F:23])[CH:8]=[CH:7][CH:6]=2)[N:9]=[C:10]([CH:11]([CH3:12])[CH3:13])[C:14]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

3

Reactant 1

HCID 86735940HCID 86735940, compound

Product 1

HCID 178468890HCID 178468890, compound

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

A solution of 16 g of the product of Step C in 16ml of phenyl oxide was heated for 15 minutes on a bath at 240° C and the ethanol was distilled. The phenyl oxide was evaporated to obtain ethyl 4-hydroxy-2-isopropyl-8-trifluoromethylquinoline-3-carboxylate as a brown oil which was used as is for the next step.

Workup

  1. distillationthe ethanol was distilled
  2. customThe phenyl oxide was evaporated

Sources & evidence

ORD record
ord-e3b5e7aca7544f6b84229ab843f2640b
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

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