HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → HCID 178441520, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | HCID 178441522 | HCID 178441522 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178441520 | HCID 178441520 | 31.9% |
Reaction Steps
Using the procedure of Step F of Example 6, 10.02 g of the product of Step E and 3.2 g of 2-aminothiazole were reacted in the presence of dicyclohexylcarbodiimide in dimethylformamide to obtain 4.03 g of N-(2-thiazolyl)-4-hydroxy-2-(2-methylpropyl)-8-trifluoromethyl-quinoline-3-carboxamide in the form of colorless crystals melting at 170°-171° C after crystallization from isopropanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04107310 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-70256335b4cc4e82a29c1e4aba25ad65 |
| Source note | uspto-grants-1978_08 |