Diphenyl Ether → HCID 178468496, compound

HRID 2419829Notes

Reaction equation

[C:1]1([C:7]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[C:24]([F:27])([F:26])[F:25])=[C:8]([C:14]([O-])=[O:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(OC2C=CC=CC=2)C=CC=CC=1>>[OH:15][C:14]1[C:23]2[C:18](=[C:19]([C:24]([F:25])([F:27])[F:26])[CH:20]=[CH:21][CH:22]=2)[N:17]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:8]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10]

Participants

Reactant 2

HCID 7583Diphenyl Ether

HCID 86735942HCID 86735942, compound

Product 1

HCID 178468496HCID 178468496, compoundYield 78.2%

Procedure

Using the procedure of Step D of Example 6, 31.56 g of the product of Step C and 32 ml of phenyl oxide were reacted to obtain 23.56 g of ethyl 4-hydroxy-2-phenyl-8-trifluoromethyl-quinoline-3-carboxylate melting at 114° C which was used as is for the next step.

Workup

customwere reacted

Sources & evidence

ORD record: ord-ce75ef5574be4924939b1321ab533275
Source dataset: uspto-grants-1978_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04107310

Reaction notes

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