反应详情

Using the procedure of Step E of Example 6, 12.64 g of the product of Step D in 35 ml of 36° Be sodium hydroxide and 70 ml of 95% ethanol were refluxed for 51/2 hours to obtain 9.06 g of 4-hydroxy-2-phenyl-8-trifluoromethyl-quinoline-3-carboxylic acid melting at 204° C which was used as is for the next step.

1. temperaturewere refluxed for 51/2 hours