HCID 178468496, compound → HCID 178524032, compound

HRID 2419830Notes

Reaction equation

HRID 2419830 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:3]=1[C:22]([O:24]CC)=[O:23]>C(O)C>[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:13])[F:14])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:3]=1[C:22]([OH:24])=[O:23]

Participants

3

Reactant 1

HCID 178468496HCID 178468496, compound

Product 1

HCID 178524032HCID 178524032, compoundYield 77.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using the procedure of Step E of Example 6, 12.64 g of the product of Step D in 35 ml of 36° Be sodium hydroxide and 70 ml of 95% ethanol were refluxed for 51/2 hours to obtain 9.06 g of 4-hydroxy-2-phenyl-8-trifluoromethyl-quinoline-3-carboxylic acid melting at 204° C which was used as is for the next step.

Workup

  1. temperaturewere refluxed for 51/2 hours

Sources & evidence

ORD record
ord-6f0f98a2252b46b88c9f00e1f6dd750c
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

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