HCID 178468615, compound → HCID 178524115, compound

HRID 2419832Notes

Reaction equation

HRID 2419832 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:3]=1[C:23]([O:25]CC)=[O:24]>C(O)C>[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:13])[F:14])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:3]=1[C:23]([OH:25])=[O:24]

Participants

3

Reactant 1

HCID 178468615HCID 178468615, compound

Product 1

HCID 178524115HCID 178524115, compoundYield 83.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using the procedure of Step E of Example 6, a mixture of 9.4 g of the product of Step D, 25.2 ml of 36° Be sodium hydroxide and 51 ml of 95% ethanol was refluxed for 6 hours to obtain 7.3 g of 4-hydroxy-2-phenylmethyl-8-trifluoromethyl-quinoline-3-carboxylic acid melting at 252° C which was used as is for the next step.

Workup

  1. temperaturewas refluxed for 6 hours

Sources & evidence

ORD record
ord-d829d18cca274e8d8a39e888273e3842
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

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