HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178522550, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | HCID 178524115 | HCID 178524115 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 178522550 | HCID 178522550 | 26.1% |
Reaction Steps
Using the procedure of Step F of Example 6, 8.6 g of the product of Step E and 2.47 g of 2-amino-thiazole were reacted in the presence of 5.59 g of dicyclohexylcarbodiimide in 125 ml of dimethylformamide to obtain a raw product which was dissolved in aqueous N sodium hydroxide. Addition of hydrochloric acid yielded 2.76 g of N-(2-thiazolyl)-4-hydroxy-2-phenylmethyl-8-trifluoromethyl-quinoline-3-carboxamide in the form of slightly ocre colored crystals melting at 256° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04107310 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-b3cfaa9a0d4743e38a4e4fa11c4145c2 |
| Source note | uspto-grants-1978_08 |