反应详情

40% -Formaldehyde solution (3 ml.) and 4%-sodium hydrogen carbonate solution (6 ml.) were added to a solution of [7β-Phenylacetamido-4-(2,2,2-trichloroethoxy-carbonyl)ceph-3-em-3-ylmethyl]-triphenylphosphonium bromide (403 mg., 0.5 mmole) in methylene chloride (10 ml.), and the two phase mixture was stirred vigorously for 25 minutes. The organic phase was washed with 2N-hydrochloric acid and water (10 ml of each), dried (MgSO4), and evaporated to an orange oil which was crystallised from ethanol (ca. 2 ml.) to give the title ester (22 mg., 9%), λmax. (EtOH) 297 nm (ε 14,100).

1. washThe organic phase was washed with 2N-hydrochloric acid and water (10 ml of each),
2. dry with materialdried (MgSO4)
3. customevaporated to an orange oil which
4. customwas crystallised from ethanol (ca. 2 ml.)