Diazomethane → HCID 13384245, compound

HRID 2419920Notes

Reaction equation

HRID 2419920 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:23]=[CH:22][C:11]([O:12][C:13]([CH3:21])([C:17]([F:20])([F:19])[F:18])[C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[N+](=[CH2:26])=[N-]>CCOCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([O:12][C:13]([CH3:21])([C:17]([F:18])([F:19])[F:20])[C:14]([O:16][CH3:26])=[O:15])=[CH:22][CH:23]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 13384246HCID 13384246, compound

Product 1

HCID 13384245HCID 13384245, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of (±)-2-[4-(4-chlorophenyl)phenoxy]-3,3,3-trifluoro-2-methylpropionic acid (3.0 g.) in ether (100 ml.) is treated with an excess of ethereal diazomethane at 0° C. The solvent is evaporated and the residue recrystallised from methanol to give (±)-methyl 2-[4-(4-chlorophenyl)phenoxy]-3,3,3-trifluoro-2-methylpropionate, m.p. 87°-88° C.

Workup

  1. customThe solvent is evaporated
  2. customthe residue recrystallised from methanol

Sources & evidence

ORD record
ord-adef97e96fb449c9970ff11b7e2efb18
Source dataset
uspto-grants-1978_08
Patent number
US04107329

Reaction notes

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