Hydrochloric Acid → HCID 86735951, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 30 grams of sodium hydroxide, 5 grams of tetrabutylammonium bromide, 60 milliliters of water and 250 milliliters of benzene is heated to 70° C. and to it is added over a period of 5 hours a solution of 127.5 grams of 3,5-di-t-butyl-4-hydroxybenzyl chloride and 17.5 grams of propionaldehyde in 125 milliliters of benzene. The reaction mixture is stirred for an additional 30 minutes at 70° C. and is then neutralized by the addition of a solution of 50 milliliters of concentrated hydrochloric acid in 100 milliliters of water. The layers are separated and benzene is removed from the organic layer on a rotary evaporator. The viscous residue crystallizes on mixing with hexane and the solid is separated by filtration. There is obtained 67.5 grams of 2,2-bis(3,5-ditert.butyl-4-hydroxybenzyl propionaldehyde.

Provenance & Evidence