反应详情

A solution of 14.5 g. (0.05 mol.) of N-t-butoxycarbonyl-2-acetoxyglycine n-butyl ester and 10 ml. of redistilled pyrrole in 75 ml. of toluene was slowly distilled with replacement of fresh toluene to maintain the volume at 50-75 ml. After 30 minutes the reaction mixture was cooled and concentrated in vacuo. The residue was dissolved in hexane and chromatographed on alumina (Woelm, activity II) with hexane-benzene followed by benzene to give the title compound.

1. distillationof toluene was slowly distilled with replacement of fresh toluene
2. temperatureto maintain the volume at 50-75 ml
3. temperatureAfter 30 minutes the reaction mixture was cooled
4. concentrationconcentrated in vacuo
5. dissolutionThe residue was dissolved in hexane
6. customchromatographed on alumina (Woelm, activity II) with hexane-benzene