反应详情

A solution of 0.91 g. (3.0 mmol.) of N-(β,β,β-trichloroethoxycarbonyl)-2-acetoxyglycine n-butyl ester and 0.3 g. (2.8 mmol.) of anisole in 20 ml. of methylene chloride containing two drops of boron trifluoride etherate was maintained at 25° for 5 hours. The solvent was then evaporated in vacuo and 2:1 hexane-methylene chloride was added. Chromatography on silica gel with methylene chloride containing increasing amounts of ethyl acetate gave the title compound.

1. customThe solvent was then evaporated in vacuo and 2:1 hexane-methylene chloride
2. additionwas added
3. temperatureChromatography on silica gel with methylene chloride containing increasing amounts of ethyl acetate