Hydrochloric Acid → HCID 70624115, compound

HRID 2420103Notes

Reaction equation

HRID 2420103 reaction equation
[NH:1]([C:5]1[CH:21]=[CH:20][C:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]([O:18]C)=[O:17])=[N:14][CH:15]=2)=[CH:7][CH:6]=1)C(C)=O.[ClH:22]>>[ClH:22].[ClH:22].[NH2:1][C:5]1[CH:21]=[CH:20][C:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]([OH:18])=[O:17])=[N:14][CH:15]=2)=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 20313028HCID 20313028, compound

Product 1

HCID 70624115HCID 70624115, compound

Procedure

0.8 Gram of methyl 5-(4-acetaminobenzyl)picolinate and 20 ml. of concentrated hydrochloric acid were heated under reflux for 3 hours. Then, concentrated hydrochloric acid was distilled out under reduced pressure. Ethyl alcohol was added thereto and thus resulting crystals were collected by filtration and dried at room temperature under reduced pressure to obtain 0.7 g of 5-(4-aminobenzyl)picolinic acid dihydrochloride as colorless crystals of a decomposition point of 217°-223° C.

Workup

  1. temperatureunder reflux for 3 hours
  2. distillationThen, concentrated hydrochloric acid was distilled out under reduced pressure
  3. additionEthyl alcohol was added
  4. customthus resulting crystals
  5. filtrationwere collected by filtration
  6. customdried at room temperature under reduced pressure

Sources & evidence

ORD record
ord-baee95e0a58e491c84b76f60def80ca2
Source dataset
uspto-grants-1978_08
Patent number
US04109000

Reaction notes

Loading…