Hydrochloric Acid → HCID 20313024, compound

HRID 2420109Notes

Reaction equation

HRID 2420109 reaction equation
[CH2:1]([C:8]1[CH:9]=[CH:10][C:11]([C:14]([OH:16])=[O:15])=[N:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH2:18](O)[CH3:19]>>[CH2:1]([C:8]1[CH:9]=[CH:10][C:11]([C:14]([O:16][CH2:18][CH3:19])=[O:15])=[N:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 30428422-Pyridinecarboxylic acid, 5-(phenylmethyl)-

Product 1

HCID 20313024HCID 20313024, compound

Procedure

2.0 Grams of 5-benzylpicolinic acid were suspended in 25 ml. of ethanol. The resulting suspension was saturated with hydrogen chloride gas under ice-cooling. After reflux for three hours, the reaction solution was concentrated under reduced pressure. Ether was added thereto to form crystals. The crystals were then recrystallized from a solvent comprising a mixture of acetone/ether to obtain 1.7 g of ethyl 5-benzylpicolinate of a melting point of 109°~111° C.

Workup

  1. temperaturecooling
  2. temperatureAfter reflux for three hours
  3. concentrationthe reaction solution was concentrated under reduced pressure
  4. additionEther was added
  5. customto form crystals
  6. customThe crystals were then recrystallized from a solvent comprising
  7. additiona mixture of acetone/ether

Sources & evidence

ORD record
ord-60ae81fb857d426eba9005aab5bb7eeb
Source dataset
uspto-grants-1978_08
Patent number
US04109000

Reaction notes

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