HCID 20311078, compound → HCID 20311079, compound

HRID 2420203Notes

Reaction equation

HRID 2420203 reaction equation
[N+:1]([C:4]1[C:5]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])=[CH:6][C:7]([NH2:23])=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH:9]=1)([O-])=O>C(O)C.[Ni]>[NH2:23][C:7]1[CH:6]=[C:5]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])[C:4]([NH2:1])=[CH:9][C:8]=1[O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Participants

4

Reactant 1

HCID 20311078HCID 20311078, compound

Product 1

HCID 20311079HCID 20311079, compoundYield 74.4%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

The product of Stage 5 (4.0 g) is dissolved with heating in 250 ml of ethanol and catalytically hydrogenated with Raney nickel at 50° C./50 atms pressure. Concentration of the hydrogenation solution after the nickel has been filtered off under suction gives 2.8 g of a product melting at 75°-76° C.

Workup

  1. filtrationConcentration of the hydrogenation solution after the nickel has been filtered off under suction

Sources & evidence

ORD record
ord-aaae87a00ec9468ebdad887762179cd2
Source dataset
uspto-grants-1978_08
Patent number
US04110113

Reaction notes

Loading…