反应详情

To a mixture of 68.4 g. of 2-amino-5-methyl-4,6-dichloro-phenol hydrochloride and 96 ml. of N,N-diethylaniline in 750 ml. of acetone, 23.4 ml. of acetyl chloride were added slowly by keeping the temperature under 20° C. At the end, the reaction mixture was heated to reflux for an hour. After cooling, the solution was poured into water; the solid product, thus obtained, was collected on a buckner, washed with water until the washings were neutral and dried in a desicator at 50° C. The raw product obtained was purified by crystallization from ethyl alcohol, yielding 44 g. of a pure product with M.P. = 175°-176.5° C.

1. additionTo a mixture of 68.4 g
2. customunder 20° C
3. temperatureAt the end, the reaction mixture was heated
4. temperatureto reflux for an hour
5. temperatureAfter cooling
6. customthe solid product, thus obtained
7. customwas collected on a buckner
8. washwashed with water until the washings
9. customdried in a desicator at 50° C