Sulfuric Acid → 1-Acetyl-6-methyldihydropyrimidine-2,4(1H,3H)-dione

HRID 2420218Notes

Reaction equation

HRID 2420218 reaction equation
[CH3:1][CH:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH2:3]1.[C:10](OC(=O)C)(=[O:12])[CH3:11].OS(O)(=O)=O>>[C:10]([N:7]1[CH:2]([CH3:1])[CH2:3][C:4](=[O:9])[NH:5][C:6]1=[O:8])(=[O:12])[CH3:11]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 97818Dihydro-6-methyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 544170151-Acetyl-6-methyldihydropyrimidine-2,4(1H,3H)-dione

Procedure

In the manner described above, 65 gm (0.5 mol) of 6-methyl-5,6-dihydrouracil were reacted with 8 mols of acetic acid anhydride in the presence of 2 ml of H2SO4. The product recrystallized from isopropanol had a melting point of 107° C to 109° C and the following analysis values:

Workup

  1. customThe product recrystallized from isopropanol

Sources & evidence

ORD record
ord-62d2ddad5bea4f4e83f5cef4a1dad2af
Source dataset
uspto-grants-1978_08
Patent number
US04110242

Reaction notes

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