Ketene → HCID 54184302, compound

HRID 2420220Notes

Reaction equation

HRID 2420220 reaction equation
[CH3:1][CH:2]1[CH2:7][NH:6][C:5](=[O:8])[NH:4][C:3]1=[O:9].[CH2:10]=[C:11]=[O:12].[C:13]([O-])(=[O:15])[CH3:14].[Na+]>C(OCC)(=O)C>[C:11]([N:6]1[CH2:7][CH:2]([CH3:1])[C:3](=[O:9])[N:4]([C:13](=[O:15])[CH3:14])[C:5]1=[O:8])(=[O:12])[CH3:10]

Participants

5

Reactant 3

HCID 10038KeteneHCID 93556Dihydro-5-methyl-2,4(1H,3H)-pyrimidinedioneHCID 517045Sodium Acetate

Product 1

HCID 54184302HCID 54184302, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

As described in IV, 18.2 gm (0.14 mol) of 5-methyl-5,6-dihydrouracil were reacted with ketene in boiling ethyl acetate in the presence of sodium acetate. The product recrystallized from isopropanol had the following analysis values and a melting point of 130° C to 131° C:

Workup

  1. customThe product recrystallized from isopropanol

Sources & evidence

ORD record
ord-ec0f381ca48c4f78ae17065e47823d41
Source dataset
uspto-grants-1978_08
Patent number
US04110242

Reaction notes

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