Ketene → HCID 53790164, compound

HRID 2420221Notes

Reaction equation

HRID 2420221 reaction equation
[CH3:1][CH:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH2:3]1.[CH2:10]=[C:11]=[O:12].[C:13]([O-])(=[O:15])[CH3:14].[Na+]>C(OCC)(=O)C>[C:11]([N:7]1[CH:2]([CH3:1])[CH2:3][C:4](=[O:9])[N:5]([C:13](=[O:15])[CH3:14])[C:6]1=[O:8])(=[O:12])[CH3:10]

Participants

5

Reactant 3

HCID 10038KeteneHCID 97818Dihydro-6-methyl-2,4(1H,3H)-pyrimidinedioneHCID 517045Sodium Acetate

Product 1

HCID 53790164HCID 53790164, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In the manner described in IV above, 16.9 gm (0.13 mol) of 6-methyl-5,6-dihydrouracil were reacted with ketene in boiling ethyl acetate in the presence of sodium acetate. The product was recrystallized from a mixture of benzine (b.p. 70° C. to 95° C.) and isopropanol in the volume ratio of 1:1. The melting point was 84° C. to 86° C., and the elementary analysis resulted in the following values:

Workup

  1. customThe product was recrystallized from a mixture of benzine (b.p. 70° C. to 95° C.) and isopropanol in the volume ratio of 1:1
  2. customThe melting point was 84° C. to 86° C., and the elementary analysis resulted in the following values

Sources & evidence

ORD record
ord-3b066f174be24633a053cbc43d4760a4
Source dataset
uspto-grants-1978_08
Patent number
US04110242

Reaction notes

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