3-Fluorobenzylamine → HCID 56847143, compound

HRID 242033Notes

Reaction equation

[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=2)[C:5]([CH3:16])=[C:4]([C:17]([OH:19])=O)[C:3]1=[S:20].[F:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][NH2:26]>>[F:21][C:22]1[CH:23]=[C:24]([CH2:25][NH:26][C:17]([C:4]2[C:3](=[S:20])[N:2]([CH3:1])[C:11]3[C:6]([C:5]=2[CH3:16])=[CH:7][CH:8]=[C:9]([C:12]([F:15])([F:13])[F:14])[CH:10]=3)=[O:19])[CH:27]=[CH:28][CH:29]=1

Participants

Reactant 2

HCID 668533-Fluorobenzylamine

HCID 86662688HCID 86662688, compound

Product 1

HCID 56847143HCID 56847143, compoundYield 42%

Procedure

Reaction of 220 mg (0.73 mmol) 1,4-dimethyl-2-thioxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid with 3-fluoro-benzylamine according to the method described under example 2 Section a) yielded 125 mg (0.3 mmol, 42%) N-[(3-fluorophenyl)-methyl]-1,4-dimethyl-2-thioxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide (example 3). MS: m/z 409.1 [M+H]+.

Sources & evidence

ORD record: ord-4dcba4f1a04b4e36b3677852b3555942
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08653102B2

Reaction notes

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