Sodium Hydroxide → HCID 20311664, compound

HRID 2420469Notes

Reaction equation

HRID 2420469 reaction equation
Cl.C([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH:17]([NH:19][CH2:20][CH:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH3:18])=[CH:12][CH:11]=1)C1C=CC=CC=1.[OH-].[Na+]>[Pd].C(O)C>[OH:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH:17]([NH:19][CH2:20][CH:21]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH3:18])=[CH:14][CH:15]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 20540376HCID 20540376, compound

Product 1

HCID 20311664HCID 20311664, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The starting material is prepared as follows: The mixture of 4.6 g of dl-1-(4-benzyloxyphenyl)-2-(2,2-diphenylethylamino)-propane hydrochloride, 0.4 g of sodium hydroxide, 50 ml of ethanol and 0.5 g of 10% palladium on carbon is shaken under hydrogen at 3 atmospheres for 72 hours. The mixture is filtered and the filtrate evaporated, to afford the 1-(4-hydroxyphenyl)-2-(2,2-diphenylethylamino)-propane, which is used without further purification.

Workup

  1. customThe starting material is prepared
  2. filtrationThe mixture is filtered
  3. customthe filtrate evaporated

Sources & evidence

ORD record
ord-e6d3f11a09c3461caa32fedfad5dd9a1
Source dataset
uspto-grants-1978_08
Patent number
US04110457

Reaction notes

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