Methanol → HCID 20335783, compound

HRID 2420473Notes

Reaction equation

HRID 2420473 reaction equation
[C:1]([C:9]1[C:14]([N+:15]([O-:17])=[O:16])=[CH:13][CH:12]=[C:11](Cl)[N:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na].[CH3:20][OH:21]>O>[C:1]([C:9]1[C:14]([N+:15]([O-:17])=[O:16])=[CH:13][CH:12]=[C:11]([O:21][CH3:20])[N:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 20520021HCID 20520021, compound

Product 1

HCID 20335783HCID 20335783, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

60 grams of 2-benzoyl-3-nitro-6-chloropyridine were added in portions to a solution of 10 grams of sodium metal in 500 ml. of methanol at 50° C. with stirring, whereby the temperature gradually increased. Then the mixture was heated under reflux for four hours and subsequently treated with two liters of water. The precipitated crystals were filtered off with suction after one hour and recrystallized from methanol.

Workup

  1. temperaturewhereby the temperature gradually increased
  2. temperatureThen the mixture was heated
  3. temperatureunder reflux for four hours
  4. filtrationThe precipitated crystals were filtered off with suction after one hour
  5. customrecrystallized from methanol

Sources & evidence

ORD record
ord-7af80c4f6d27460e91bc78e94813c23e
Source dataset
uspto-grants-1978_08
Patent number
US04110455

Reaction notes

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