Hydrochloric Acid → HCID 20311843, compound

HRID 2420525Notes

Reaction equation

HRID 2420525 reaction equation
[C:1]1([CH:7]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:8]2[CH2:12][CH:11]([CH2:13][O:14][C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=3)[O:10]C2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C(C2C=CC=CC=2)N2CC(CCl)OC2)C=CC=CC=1.ClC1C=C([O-])C=CC=1Cl.[Na+].Cl>>[ClH:21].[Cl:22][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][C:18]=1[Cl:21])[O:14][CH2:13][CH:11]([OH:10])[CH2:12][NH:8][CH:7]([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 20311821HCID 20311821, compoundHCID 20311883HCID 20311883, compoundHCID 23663691Sodium 3,4-dichlorophenolate

Product 1

HCID 20311843HCID 20311843, compound

Procedure

3-Diphenylmethyl-5-(3,4-dichloro-phenoxymethyl)-oxazolidine from 3-diphenylmethyl-5-chloromethyl-oxazolidine and sodium 3,4-dichlorophenolate; this product is hydrolysed with alcoholic-aqueous hydrochloric acid to give 1-(3,4-dichlorophenoxy)-2-hydroxy-3-diphenylmethylaminopropane hydrochloride with a melting point of 180°-184°.

Sources & evidence

ORD record
ord-7643f0eca630413eaaf36b0b7634a642
Source dataset
uspto-grants-1978_08
Patent number
US04110472

Reaction notes

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