HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-(Indol-3-ylmethyl)-3-[3-(4-phenyl-1-piperidyl)propyl]hydantoin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-(3-Chloropropyl)-4-phenylpiperidine | HCID 203689 | — |
| Reactant | 5-(1h-Indol-3-ylmethyl)imidazolidine-2,4-dione | HCID 242867 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(Indol-3-ylmethyl)-3-[3-(4-phenyl-1-piperidyl)propyl]hydantoin | HCID 20312088 | — |
Reaction Steps
A mixture of 5-(indol-3-ylmethyl)hydantoin (6.4 g, 0.028 mole), 1-(3-chloropropyl)-4-phenylpiperidine (6.6 g, 0.028 mole) and 200 ml of DMF in 200 ml of anhydrous C2H5OH and 0.028 mole of NaOC2H5 was heated under reflux with stirring for 10 hours. The mixture was filtered and the filtrate was diluted with H2O. The solid was collected and twice recrystallized from aqueous C2H5OH, yield 2.0 g, mp 179°-80°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04110536 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-2790ea9f42f44c8e8957db5bb79757ec |
| Source note | uspto-grants-1978_08 |