反应详情

A mixture of 5-(indol-3-ylmethyl)hydantoin (6.4 g, 0.028 mole), 1-(3-chloropropyl)-4-phenylpiperidine (6.6 g, 0.028 mole) and 200 ml of DMF in 200 ml of anhydrous C2H5OH and 0.028 mole of NaOC2H5 was heated under reflux with stirring for 10 hours. The mixture was filtered and the filtrate was diluted with H2O. The solid was collected and twice recrystallized from aqueous C2H5OH, yield 2.0 g, mp 179°-80°.

1. temperaturewas heated
2. temperatureunder reflux
3. filtrationThe mixture was filtered
4. additionthe filtrate was diluted with H2O
5. customThe solid was collected
6. customtwice recrystallized from aqueous C2H5OH, yield 2.0 g, mp 179°-80°