HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → 3-(4'-Fluoro-4-biphenylyl)butylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 4-(4-Chlorobutan-2-yl)-4'-fluoro-1,1'-biphenyl | HCID 20302014 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4'-Fluoro-4-biphenylyl)butylamine | HCID 20302108 | — |
Reaction Steps
A solution of 33.3 g of N-benzyl-3-(4'-fluoro-4-biphenylyl)-1-butylamine [obtainable by reacting 3-(4'-fluoro-4-biphenylyl)-butanol with SOCl2 ] to give 1-chloro-3-(4'-fluoro-4-biphenylyl)-butane and reaction with benzylamine in 500 ml of methanol is hydrogenated over 8 g of 5% Pd-on-charcoal at 20° and normal pressure. After filtration and evaporation, 3-(4'-fluoro-4-biphenylyl)-butylamine is obtained. Hydrochloride, m.p. 222°-224°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04110447 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-bdd66dc51b7c4aec84e8665b03487109 |
| Source note | uspto-grants-1978_08 |