Hydrazine → HCID 70595361, compound

HRID 2420597Notes

Reaction equation

HRID 2420597 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([OH:12])[CH3:11])[CH2:4][CH2:3]1.[OH-].[K+].NN>C(O)COCCO>[N:5]1([CH2:8][CH2:9][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([OH:12])[CH3:11])[CH2:4][CH2:3][CH2:2][CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 9321HydrazineHCID 14797Potassium HydroxideHCID 70595588HCID 70595588, compound

Product 1

HCID 70595361HCID 70595361, compound

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

A mixture of 3.23 g of 1-(4-oxopiperidino)-3-p-biphenylyl-butan-3-ol (obtainable from 1-chloro-3-p-biphenylyl-butan-3-ol and 4-piperidone), 1.5 g of KOH, 2.5 ml of 85% hydrazine and 25 ml of diethylene glycol is warmed at 100° for 1 hour. The temperature is raised slowly until the hydrazone is decomposed, and the mixture is boiled for a further 4 hours, cooled and worked up in the customary manner to give 1-piperidino-3-p-biphenylyl-butan-3-ol, m.p. 102° - 104°.

Workup

  1. temperatureis warmed at 100° for 1 hour
  2. temperaturecooled

Sources & evidence

ORD record
ord-d6a0b5d0201e4bffb8c13ba0f5ed24f8
Source dataset
uspto-grants-1978_08
Patent number
US04110447

Reaction notes

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