p-Toluenesulfonic acid → HCID 54571361, compound

HRID 2420609Notes

Reaction equation

HRID 2420609 reaction equation
C1(C)C=CC(S(O)(=O)=O)=CC=1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25](O)([CH3:29])[CH2:26][CH2:27][NH2:28])=[CH:21][CH:20]=2)=[CH:15][CH:14]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.[OH-].[Na+]>C1(C)C=CC=CC=1>[F:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25]([CH3:29])=[CH:26][CH2:27][NH2:28])=[CH:21][CH:20]=2)=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 14798Sodium HydroxideHCID 20302325HCID 20302325, compound

Product 1

HCID 54571361HCID 54571361, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

25.9 g of 3-(4'-fluoro-4-biphenylyl)-3-hydroxybutylamine p-toluenesulfonate are boiled with 1 g of p-toluenesulfonic acid in 500 ml of toluene for 2 hours under a water separator, and the mixture is cooled and worked up with sodium hydroxide solution to give 3-(4'-fluoro-4-biphenylyl)-2-buten-1-yl-amine.

Workup

  1. temperatureseparator, and the mixture is cooled

Sources & evidence

ORD record
ord-79e16b000d114136a7e0346fd1fe0753
Source dataset
uspto-grants-1978_08
Patent number
US04110447

Reaction notes

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